77016-85-4
Chemical Structure
Plomestane
- CAS No.: 77016-85-4
- Formula:C21H26O2
- Molecular Weight:310.44
IUPAC Name: (8R,9S,10S,13S,14S)-13-methyl-10-(prop-2-yn-1-yl)-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione
InChIKey: JKPDEYAOCSQBSZ-OEUJLIAZSA-N
SMILES: C(C#C)[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)C(=O)CC4)[H])(CCC1=CC(=O)CC2)[H])[H]
Biological Activity: Plomestane is an orally active second-generation steroidal aromatase inhibitor that, as an enzyme-activated pseudosubstrate, is converted via NADPH-dependent catalysis into a reactive intermediate, which covalently binds to aromatase to produce irreversible inhibition, thereby persistently suppressing peripheral aromatase activity. Plomestane can be used for the study of hormone-dependent breast cancer[1][2].
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Plomestane | Plomestane is an orally active second-generation steroidal aromatase inhibitor that, as an enzyme-activated pseudosubstrate, is converted via NADPH-dependent catalysis into a reactive intermediate, which covalently binds to aromatase to produce irreversible inhibition, thereby persistently suppressing peripheral aromatase activity. Plomestane can be used for the study of hormone-dependent breast cancer. | |||||||||||||||||||||
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