80214-88-6
Chemical Structure
Ruboxyl
- CAS No.: 80214-88-6
- Formula:C36H47ClN4O10
- Molecular Weight:731.23
IUPAC Name: (8S,10S)-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-((Z)-1-((1-hydroxy-2,2,6,6-tetramethylpiperidin-4-ylidene)hydrazono)ethyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
InChIKey: GYPCWHHQAVLMKO-BFPFSNHBSA-N
SMILES: O=C1C2=C(C3=C(C(O)=C2C(C4=C1C=CC=C4OC)=O)[C@@H](O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N)C[C@@](/C(C)=N\N=C6CC(C)(N(C(C)(C/6)C)O)C)(O)C3)O.Cl
Biological Activity: Ruboxyl is an anthracycline antibiotic with antitumor activity. Ruboxyl inhibits colorectal cancer (CRC) liver metastasis in mice by 84%, suppresses B16 melanoma growth, and increases the survival rate of mice with L1210 or L5178Y leukemia[1][2].
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Ruboxyl | Ruboxyl is an anthracycline antibiotic with antitumor activity. Ruboxyl inhibits colorectal cancer (CRC) liver metastasis in mice by 84%, suppresses B16 melanoma growth, and increases the survival rate of mice with L1210 or L5178Y leukemia. | |||||||||||||||||||||
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References
- [1]. Leonetti C, et al. Ruboxyl, a new nitroxyl derivative of daunorubicin - acute toxicity and antitumor effect in animals. Int J Oncol. 1993 Oct;3(4):615-8. [Content Brief]
- [2]. Sirovich I, et al. Activity of ruboxyl, a nitroxyl derivative of daunorubicin, on experimental models of colorectal cancer metastases. Tumour Biol. 1999 Sep-Oct;20(5):270-6. [Content Brief]
