80330-39-8
Chemical Structure
8-Acetonyldihydronitidine
- CAS No.: 80330-39-8
- Formula:C24H23NO5
- Molecular Weight:405.45
IUPAC Name: 1-(2,3-dimethoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-13-yl)propan-2-one
InChIKey: OLYNXAXGZUKQDD-UHFFFAOYSA-N
SMILES: O=C(C)CC1C2=CC(OC)=C(OC)C=C2C=3C=CC4=CC=5OCOC5C=C4C3N1C
Biological Activity: 8‑Acetonyldihydronitidine is a naturally occurring benzophenanthridine alkaloid with antibacterial, antifungal, and anti-proliferative activities against colorectal cancer cells. 8‑Acetonyldihydronitidine inhibits Staphylococcus aureus and exerts a potent antifungal effect against Cladosporium cladosporioides. 8‑Acetonyldihydronitidine activates the p53 signaling pathway, upregulates the expression of target genes including p21, BAX, and FAS, downregulates cyclin A and cyclin B, and induces cell cycle arrest and apoptosis, thereby suppressing the proliferation of colorectal cancer cells. 8‑Acetonyldihydronitidine is used in research related to colorectal cancer, fungal infections, and bacterial infections[1][2][3].
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8-Acetonyldihydronitidine | 8‑Acetonyldihydronitidine is a naturally occurring benzophenanthridine alkaloid with antibacterial, antifungal, and anti-proliferative activities against colorectal cancer cells. 8‑Acetonyldihydronitidine inhibits Staphylococcus aureus and exerts a potent antifungal effect against Cladosporium cladosporioides. 8‑Acetonyldihydronitidine activates the p53 signaling pathway, upregulates the expression of target genes including p21, BAX, and FAS, downregulates cyclin A and cyclin B, and induces cell cycle arrest and apoptosis, thereby suppressing the proliferation of colorectal cancer cells. 8‑Acetonyldihydronitidine is used in research related to colorectal cancer, fungal infections, and bacterial infections. | |||||||||||||||||||||
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References
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[1]. Zhou J W, et al. 8‑Acetonyldihydronitidine inhibits the proliferation of human colorectal cancer cells via activation of p53. European Journal of Pharmacology, 2019, 854: 256‑264.
- [2]. Nissanka AP, et al. Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum. Phytochemistry. 2001 Apr;56(8):857-61.
