824395-67-7
Chemical Structure
(+)-1,2-Bis((2S,5S)-2,5-diphenylphospholano)ethane
Synonym(s): (S,S)-Ph-BPE
- CAS No.: 824395-67-7
- Formula:C34H36P2
- Molecular Weight:506.60
IUPAC Name: 1,2-bis((2S,5S)-2,5-diphenylphospholan-1-yl)ethane
InChIKey: VHHAZLMVLLIMHT-CUPIEXAXSA-N
SMILES: P1([C@H](C2=CC=CC=C2)CC[C@H]1C3=CC=CC=C3)CCP4[C@H](C5=CC=CC=C5)CC[C@H]4C6=CC=CC=C6
Biological Activity: (+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane ((S,S)-Ph-BPE) is a chiral bisphosphine ligand and catalyst. (+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane acts as a chiral ligand in rhodium-catalyzed reductive hydroformylation of alkenyl boronic esters, enabling enantiodivergent synthesis of chiral γ-boryl alcohols. (+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane forms chiral nickel-phosphine complexes to mediate asymmetric hydrogenation of aliphatic γ- and δ-keto acids; protons promote substrate C=O bond activation and stereoselectivity control via hydrogen bonding. (+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane forms a monodentate nickel complex, which serves as the active species for asymmetric hydrogenation of aliphatic keto acids[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(+)-1,2-Bis((2S,5S)-2,5-diphenylphospholano)ethane | 98.0% | (+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane ((S,S)-Ph-BPE) is a chiral bisphosphine ligand and catalyst. (+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane acts as a chiral ligand in rhodium-catalyzed reductive hydroformylation of alkenyl boronic esters, enabling enantiodivergent synthesis of chiral γ-boryl alcohols. (+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane forms chiral nickel-phosphine complexes to mediate asymmetric hydrogenation of aliphatic γ- and δ-keto acids; protons promote substrate C=O bond activation and stereoselectivity control via hydrogen bonding. (+)-1,2-Bis ((2S,5S)-2,5-diphenylphospholano)ethane forms a monodentate nickel complex, which serves as the active species for asymmetric hydrogenation of aliphatic keto acids. | ||||||||||||||||||||
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References
- [1]. Yu Y, et al. Enantiodivergent Rh-Catalyzed Reductive Hydroformylation of Alkenyl Boronic Esters. Angew Chem Int Ed Engl. 2026;65(2):e20602. [Content Brief]
- [2]. Deng CQ, et al. Proton-Promoted Nickel-Catalyzed Asymmetric Hydrogenation of Aliphatic Ketoacids. Angew Chem Int Ed Engl. 2022;61(15):e202115983. [Content Brief]
