847939-23-5
847939-23-5
Chemical Structure
SR-4559
- CAS No.: 847939-23-5
- Formula:C23H24N2O6S
- Molecular Weight:456.51
IUPAC Name: 1-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)piperazin-1-yl)-2-(6-methylbenzofuran-3-yl)ethan-1-one
InChIKey: HJVYLFAPJPGKEE-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(OCCO2)C2=C1)(N3CCN(C(CC4=COC5=C4C=CC(C)=C5)=O)CC3)=O
Biological Activity: SR-4559 is a α/β hydrolase domain-containing protein 5 (ABHD5) ligand. SR-4559 activates adipose triglyceride lipase (ATGL) and stimulates lipolysis by inhibiting ABHD5-PLIN interactions in adipocytes and muscle cells. SR-4559 can be used for metabolic diseases like Chanarin Dorfman syndrome research[1][2].
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SR-4559 | 98.81% | SR-4559 is a α/β hydrolase domain-containing protein 5 (ABHD5) ligand. SR-4559 activates adipose triglyceride lipase (ATGL) and stimulates lipolysis by inhibiting ABHD5-PLIN interactions in adipocytes and muscle cells. SR-4559 can be used for metabolic diseases like Chanarin Dorfman syndrome research. | ||||||||||||||||||||
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References
- [1]. Sanders MA, et al. Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle. Cell Metab. 2015;22(5):851-860. [Content Brief]
- [2]. Lum KM, et al. Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017;12(10):2671-2681. [Content Brief]
