862282-10-8
Chemical Structure
PF-00446687 hydrochloride
- CAS No.: 862282-10-8
- Formula:C28H37ClF2N2O2
- Molecular Weight:507.06
IUPAC Name: ((3S,4R)-1-(tert-butyl)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3R,4S,5S)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone hydrochloride
InChIKey: WWCBDWDDPAPGHX-UZEFPFOTSA-N
SMILES: O=C(N1C[C@H]([C@@]([C@H](C1)C)(C2=CC=CC=C2)O)C)[C@H]3[C@H](C4=C(C=C(C=C4)F)F)CN(C3)C(C)(C)C.Cl
Biological Activity: PF-00446687 hydrochloride is a potent, brain-penetrating, selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 12 nM. PF-00446687 hydrochloride can be used in the research of sexual dysfunction[1][2].
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PF-00446687 hydrochloride | PF-00446687 hydrochloride is a potent, brain-penetrating, selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 12 nM. PF-00446687 hydrochloride can be used in the research of sexual dysfunction. | |||||||||||||||||||||
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- [1]. Lansdell MI, et al. Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem. 2010 Apr 22;53(8):3183-97. [Content Brief]
- [2]. Modi ME, et al. Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40(8):1856-65. [Content Brief]
Keywords
