864681-04-9
Chemical Structure
Azido-PEG4-CH2-Boc
- CAS No.: 864681-04-9
- Formula:C14H27N3O6
- Molecular Weight:333.38
IUPAC Name: tert-butyl 14-azido-3,6,9,12-tetraoxatetradecanoate
InChIKey: SIOLYQZSIFQODW-UHFFFAOYSA-N
SMILES: O=C(OC(C)(C)C)COCCOCCOCCOCCN=[N+]=[N-]
Biological Activity: Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG4-CH2-Boc | 97.0% | Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | ||||||||||||||||||||
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- [1]. Shiladitya Sengupta, et al. Targeted drug delivery through affinity based linkers. WO2015148126A1.
- [2]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. [Content Brief]
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