87164-32-7
Chemical Structure
Schisanlactone B
- CAS No.: 87164-32-7
- Formula:C30H42O4
- Molecular Weight:466.66
IUPAC Name: (5aS,6aS,8aR,9R,11aS,11bS,13aR)-1,1,8a,11a-tetramethyl-9-((S)-1-((S)-5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-1,7,8,8a,9,10,11,11a,11b,12,13,13a-dodecahydro-3H,6H-cyclopenta[5,6]cyclopropa[1,8a]naphtho[2,1-c]oxepin-3-one
InChIKey: FHMHZILQWWQUCO-UTQYRBOUSA-N
SMILES: C[C@]12[C@]3([C@]4([C@]5(C4)[C@@](CC3)(C(C)(C)OC(=O)C=C5)[H])CC[C@]1(C)[C@@]([C@H](C)[C@]6(OC(=O)C(C)=CC6)[H])(CC2)[H])[H]
Biological Activity: Schisanlactone B is a glutathione S-transferase (GST) inhibitor with an IC50 of 5 μM. Schisanlactone B binds to GST and inhibits its enzymatic activity. Schisanlactone B induces apoptosis and cell cycle arrest. Schisanlactone B can be used in research related to various cancers such as hepatocellular carcinoma, leukemia, melanoma, lung cancer, gastric cancer, and breast cancer[1][2][3][4][5][6].
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Schisanlactone B | Schisanlactone B is a glutathione S-transferase (GST) inhibitor with an IC50 of 5 μM. Schisanlactone B binds to GST and inhibits its enzymatic activity. Schisanlactone B induces apoptosis and cell cycle arrest. Schisanlactone B can be used in research related to various cancers such as hepatocellular carcinoma, leukemia, melanoma, lung cancer, gastric cancer, and breast cancer. | |||||||||||||||||||||
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References
- [1]. Mao L, et al. Rapid discovery of a novel "green" and natural GST inhibitor for sensitizing hepatocellular carcinoma to Cisplatin by visual screening strategy. Journal of pharmaceutical analysis. 2024 May;14(5):100923.
- [2]. Wang W, et al. New triterpenoids from Kadsura heteroclita and their cytotoxic activity. Planta medica. 2006 Apr;72(5):450-7. [Content Brief]
- [3]. Chen YG, et al. Triterpenoids from Schisandra henryi with cytotoxic effect on leukemia and Hela cells in vitro. Archives of pharmacal research. 2003 Nov;26(11):912-6.
- [4]. Tram LH. A new triterpenoid from the stems of Kadsura coccinea with antiproliferative activity. Natural product research. 2022 May 23;36(10):2542-6.
- [5]. Yu HY, et al. Triterpenoids from the fruit of Schisandra glaucescens. Fitoterapia. 2016 Sep;113:64-8.
- [6]. Lu Y, et al. Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens. Pharmaceutical biology. 2013 Sep;51(9):1204-7. [Content Brief]
