875770-32-4
Chemical Structure
Propargyl-PEG4-Tos
- CAS No.: 875770-32-4
- Formula:C18H26O7S
- Molecular Weight:386.46
IUPAC Name: 3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzenesulfonate
InChIKey: VUJIUZITHCTEAF-UHFFFAOYSA-N
SMILES: C#CCOCCOCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O
Biological Activity: Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2]. Propargyl-PEG4-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Propargyl-PEG4-Tos | Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG4-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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- [1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461. [Content Brief]
- [2]. Senthilkumar T, et al. Conjugated Polymer Nanoparticles with Appended Photo-Responsive Units for Controlled DrugDelivery, Release, and Imaging. Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13114-13119. [Content Brief]
Keywords
