886041-60-7
886041-60-7
Chemical Structure
MK3281
- CAS No.: 886041-60-7
- Formula:C29H37N3O3
- Molecular Weight:475.62
IUPAC Name: (R)-14-cyclohexyl-7-((2-(dimethylamino)ethyl)(methyl)amino)-7,8-dihydro-6H-benzo[2,3][1,5]oxazocino[5,4-a]indole-11-carboxylic acid
InChIKey: YQUCBFIQSJVCOR-JOCHJYFZSA-N
SMILES: CN(C)CCN([C@@H]1CN2C(C3=CC=CC=C3OC1)=C(C4CCCCC4)C5=CC=C(C(O)=O)C=C52)C
Biological Activity: MK3281 (Compound 33) is a non-nucleoside hepatitis C virus (HCV) NS5B polymerase inhibitor, with an EC50 of 28 nM for gt1a[1].
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MK3281 | MK3281 (Compound 33) is a non-nucleoside hepatitis C virus (HCV) NS5B polymerase inhibitor, with an EC50 of 28 nM for gt1a. | |||||||||||||||||||||
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References
- [1]. Narjes F, et al. Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem. 2011 Jan 13;54(1):289-301. [Content Brief]
