887702-61-6
887702-61-6
Chemical Structure
PF-3052334
- CAS. Nr.: 887702-61-6
- Formula:C28H33FN3NaO5
- Molecular Weight:533.57
IUPAC Name: sodium (3R,5R)-7-(1-(4-fluorophenyl)-4-isopropyl-3-((4-methylbenzyl)carbamoyl)-1H-pyrazol-5-yl)-3,5-dihydroxyheptanoate
InChIKey: VEGKDAAILHTMLD-OHIDFYLOSA-M
SMILES: O=C(O[Na])C[C@H](O)C[C@H](O)CCC1=C(C(C)C)C(C(NCC2=CC=C(C=C2)C)=O)=NN1C3=CC=C(C=C3)F
Biological Activity: PF-3052334 is an orally active, hepatically selective HMG-CoA reductase inhibitor with an IC50 of 1.9 nM. PF-3052334 inhibits cholesterol synthesis, with IC50 values of 0.9 and 730 nM in hepatocytes and muscle cells, respectively. PF-3052334 can be used to study hypercholesterolemia[1].
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PF-3052334 | PF-3052334 is an orally active, hepatically selective HMG-CoA reductase inhibitor with an IC50 of 1.9 nM. PF-3052334 inhibits cholesterol synthesis, with IC50 values of 0.9 and 730 nM in hepatocytes and muscle cells, respectively. PF-3052334 can be used to study hypercholesterolemia. | |||||||||||||||||||||
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