890605-54-6
890605-54-6
Chemical Structure
Heclin
- CAS No.: 890605-54-6
- Formula:C17H17NO3
- Molecular Weight:283.32
IUPAC Name: (E)-N-(4-acetylphenyl)-3-(5-ethylfuran-2-yl)acrylamide
InChIKey: SPTWXRJNCFIDRQ-ZHACJKMWSA-N
SMILES: CC(C(C=C1)=CC=C1NC(/C=C/C2=CC=C(CC)O2)=O)=O
Biological Activity: Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits Smurf2, Nedd4, WWP1 (IC50 values are 6.8, 6.3, 6.9 μM) and can be used for the research of gastric cancer[1][2][3].
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Heclin | 98.00% | Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits Smurf2, Nedd4, WWP1 (IC50 values are 6.8, 6.3, 6.9 μM) and can be used for the research of gastric cancer. | ||||||||||||||||||||
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References
- [1]. Wang K, et al. Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway-driven gastric cancer [J]. Oncogene, 2023, 42(14): 1072-1087. [Content Brief]
- [2]. Su B C, Chen J Y. Antimicrobial peptide epinecidin-1 modulates MyD88 protein levels via the proteasome degradation pathway [J]. Marine Drugs, 2017, 15(11): 362. [Content Brief]
- [3]. Mund T, et al. Peptide and small molecule inhibitors of HECT-type ubiquitin ligases [J]. Proceedings of the National Academy of Sciences, 2014, 111(47): 16736-16741. [Content Brief]
Keywords
