893421-54-0
Chemical Structure
Imidafenacin hydrochloride
Synonym(s): KRP-197 hydrochloride; ONO-8025 hydrochloride
- CAS No.: 893421-54-0
- Formula:C20H22ClN3O
- Molecular Weight:355.86
IUPAC Name: 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide hydrochloride
InChIKey: KOVKCGOEUKOSFQ-UHFFFAOYSA-N
SMILES: O=C(N)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3C=CN=C3C.[H]Cl
Biological Activity: Imidafenacin (KRP-197; ONO-8025) hydrochloride is an orally active inhibitor of muscarinic (mAChR) M1 and M3 receptors. Imidafenacin hydrochloride potently inhibits bladder contraction in vivo and exerts an antidiuretic effect by enhancing the signaling pathway of vasopressin (antidiuretic hormone). Imidafenacin hydrochloride can be used in research related to overactive bladder[1][2].
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Imidafenacin hydrochloride | Imidafenacin (KRP-197; ONO-8025) hydrochloride is an orally active inhibitor of muscarinic (mAChR) M1 and M3 receptors. Imidafenacin hydrochloride potently inhibits bladder contraction in vivo and exerts an antidiuretic effect by enhancing the signaling pathway of vasopressin (antidiuretic hormone). Imidafenacin hydrochloride can be used in research related to overactive bladder. | |||||||||||||||||||||
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- [1]. Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1095-102. [Content Brief]
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[2]. Kobayashi F, et al. Pharmacological effects of imidafenacin (KRP-197/ONO-8025), a new bladder selective anti-cholinergic agent, in rats. Arzneimittelforschung. 2007 Mar;57(03):147-54.
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