897026-25-4
Chemical Structure
Azurin p28 peptide
- CAS No.: 897026-25-4
- Formula:C122H197N31O47S2
- Molecular Weight:2914.18
SMILES: C([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)CO)=O)[C@@H](C)O)=O)C)=O)C)=O)CC(O)=O)=O)CCSC)=O)CCC(N)=O)=O)=O)[C@H](C)C)=O)[C@H](C)C)=O)[C@@H](C)O)=O)CC(O)=O)=O)=O)CCSC)=O)C)=O)CO)=O)=O)CC(C)C)=O)CC(O)=O)=O)CCCCN)=O)CC(O)=O)=O)=O)CC(C)C)=O)CCCCN)(=O)N2[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CC(O)=O)=O)CCC2
Biological Activity: Azurin p28 peptide is a tumor-penetrated antitumor peptide. Azurin p28 peptide redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide induces apoptosis or cell cycle arrest. Azurin p28 peptide inhibits p53-positive tumor growths. Azurin p28 peptide shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt[1][2][3].
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Azurin p28 peptide | 99.36% | Azurin p28 peptide is a tumor-penetrated antitumor peptide. Azurin p28 peptide redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide induces apoptosis or cell cycle arrest. Azurin p28 peptide inhibits p53-positive tumor growths. Azurin p28 peptide shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt. | ||||||||||||||||||||
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References
- [1]. Jia L, et al. Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination. Cancer Chemother Pharmacol. 2011 Aug;68(2):513-24. [Content Brief]
- [2]. Mehta RR, et al. A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis. 2011 Sep;14(3):355-69. [Content Brief]
- [3]. Yamada T, et al. A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol Cancer Ther. 2009 Oct;8(10):2947-58. [Content Brief]
