904672-77-1
904672-77-1
Chemical Structure
URB694
- CAS No.: 904672-77-1
- Formula:C19H21NO3
- Molecular Weight:311.37
InChIKey: KRJOFKFEYDSZAV-UHFFFAOYSA-N
SMILES: O=C(OC=1C=CC(O)=C(C1)C=2C=CC=CC2)NC3CCCCC3
Biological Activity: URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH[1][2].
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URB694 | URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH. | |||||||||||||||||||||
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References
- [1]. Carnevali L, et, al. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Sci Rep. 2015 Dec 14:5:18218. [Content Brief]
- [2]. Boileau I, et, al. Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase. J Nucl Med. 2014 Dec;55(12):1993-7. [Content Brief]
