90828-16-3
90828-16-3
Chemical Structure
cis-SU4312
Synonym(s): (Z)-SU4312
- CAS No.: 90828-16-3
- Formula:C17H16N2O
- Molecular Weight:264.32
IUPAC Name: (Z)-3-(4-(dimethylamino)benzylidene)indolin-2-one
InChIKey: UAKWLVYMKBWHMX-PTNGSMBKSA-N
SMILES: O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N(C)C)C=C3
Biological Activity: cis-SU4312 ((Z)-SU4312) inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. cis-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively. cis-SU4312 can cross blood brain barrier[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
cis-SU4312 | cis-SU4312 ((Z)-SU4312) inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. cis-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively. cis-SU4312 can cross blood brain barrier. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
