90880-23-2
90880-23-2
Chemical Structure
α-Helical CRF(9-41)
- CAS No.: 90880-23-2
- Formula:C166H274N46O53S2
- Molecular Weight:3826.40
SMILES: [DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2]
Biological Activity: α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].
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α-Helical CRF(9-41) | 98.88% | α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM. | ||||||||||||||||||||
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References
- [1]. Sonia Tucci, et al. Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacology (Berl). 2003 May;167(3):251-6. [Content Brief]
- [2]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35. [Content Brief]
