914071-54-8
Chemical Structure
Aspulvinone O
- CAS No.: 914071-54-8
- Formula:C27H28O6
- Molecular Weight:448.51
IUPAC Name: (E)-3-(2,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl)-4-hydroxy-5-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzylidene)furan-2(5H)-one
InChIKey: IAHWCROWFXOMDG-WYMPLXKRSA-N
SMILES: OC1=C(C2=CC(C/C=C(C)/C)=C(O)C=C2O)C(O/C1=C/C3=CC(C/C=C(C)/C)=C(O)C=C3)=O
Biological Activity: Aspulvinone O is a selective inhibitor of glutamate oxaloacetate aminotransferase GOT1. Aspulvinone O inhibits glutamine metabolism and reduces NADPH production, thereby inducing oxidative stress and apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. Aspulvinone O inhibits PDAC cell proliferation in vitro and tumor growth in xenograft models[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aspulvinone O | 96.0% | Aspulvinone O is a selective inhibitor of glutamate oxaloacetate aminotransferase GOT1. Aspulvinone O inhibits glutamine metabolism and reduces NADPH production, thereby inducing oxidative stress and apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. Aspulvinone O inhibits PDAC cell proliferation in vitro and tumor growth in xenograft models. | ||||||||||||||||||||
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- [1]. Sun W, et al. Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. Cell Commun Signal. 2019;17(1):111. [Content Brief]
- [2]. Yan S, et al. Discovery of GOT1 Inhibitors from a Marine-Derived Aspergillus terreus That Act against Pancreatic Ductal Adenocarcinoma. Mar Drugs. 2021 Oct 20;19(11):588. [Content Brief]
Keywords
