924270-31-5
Chemical Structure
MK-1220
- CAS No.: 924270-31-5
- Formula:C40H53N5O9S
- Molecular Weight:779.94
IUPAC Name: (33R,35S,5S)-5-cyclohexyl-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-16-methoxy-10,10-dimethyl-4,7-dioxo-2,8-dioxa-6-aza-1(1,7)-isoquinolina-3(3,1)-pyrrolidinacyclotridecaphane-35-carboxamide
InChIKey: JXYSYDXTCQGOTL-QXURCLOISA-N
SMILES: CC(C)(COC(N[C@@H](C1CCCCC1)C(N2[C@H](C(N[C@@](C3)(C(NS(=O)(C4CC4)=O)=O)[C@@H]3C=C)=O)C[C@@H](O5)C2)=O)=O)CCCC6=C(OC)C=C7C(C5=NC=C7)=C6
Biological Activity: MK-1220 is a covalently reversible inhibitor of the hepatitis C virus (HCV) NS3/4A protease (NS3/4A protease) with a Ki of 0.02 nM. MK-1220 in cell models simulating viral replication exhibits EC50s of 4 (with 10% fetal bovine serum) and 11 nM (50% normal human serum). MK-1220 can be used for the study of chronic hepatitis C virus infection[1].
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MK-1220 | MK-1220 is a covalently reversible inhibitor of the hepatitis C virus (HCV) NS3/4A protease (NS3/4A protease) with a Ki of 0.02 nM. MK-1220 in cell models simulating viral replication exhibits EC50s of 4 (with 10% fetal bovine serum) and 11 nM (50% normal human serum). MK-1220 can be used for the study of chronic hepatitis C virus infection. | |||||||||||||||||||||
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Keywords
