929095-23-8
Chemical Structure
GSK461364 analogue 1
- CAS No.: 929095-23-8
- Formula:C26H27ClN4O3S
- Molecular Weight:511.04
IUPAC Name: (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-((1-methylpiperidin-4-yl)oxy)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide
InChIKey: GILNGUYOGYOZMP-MRXNPFEDSA-N
SMILES: O(C=1C=C2N(C=NC2=CC1)C3=CC(O[C@H](C)C4=C(Cl)C=CC=C4)=C(C(N)=O)S3)C5CCN(C)CC5
Biological Activity: GSK461364 analogue 1 is a thiophene-based PLK1 inhibitor with a PLK1 IC50 of 2 nM and a PLK3 IC50 of 630 nM. GSK461364 analogue 1 also acts as an inhibitor of Nek2 kinase (IC50: 21 nM). GSK461364 analogue 1 has a solubility of ≥190 μM in pH 7.4 PBS and a human plasma protein binding rate of 91.5%. GSK461364 analogue 1 can be used in studies related to colon cancer, lung cancer, breast cancer and ovarian cancer[1].
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GSK461364 analogue 1 | GSK461364 analogue 1 is a thiophene-based PLK1 inhibitor with a PLK1 IC50 of 2 nM and a PLK3 IC50 of 630 nM. GSK461364 analogue 1 also acts as an inhibitor of Nek2 kinase (IC50: 21 nM). GSK461364 analogue 1 has a solubility of ≥190 μM in pH 7.4 PBS and a human plasma protein binding rate of 91.5%. GSK461364 analogue 1 can be used in studies related to colon cancer, lung cancer, breast cancer and ovarian cancer. | |||||||||||||||||||||
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