932013-61-1
Chemical Structure
HB43
- CAS No.: 932013-61-1
- Formula:C72H129N17O14
- Molecular Weight:1456.90
InChIKey: JGHIFBZCCKTCSR-SZGFHDAGSA-N
SMILES: N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: HB43 is a synthetic amphipathic cationic α-helical peptide, as well as an antibacterial/anticancer peptide. HB43 reduces the number of Methicillin (HY-121544)-resistant Staphylococcus aureus in biofilms in a dose-dependent manner. When loaded into chitosan nanoparticles, it achieves sustained release, and this effect is particularly pronounced under acidic conditions[1][2].
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HB43 | HB43 is a synthetic amphipathic cationic α-helical peptide, as well as an antibacterial/anticancer peptide. HB43 reduces the number of Methicillin (HY-121544)-resistant Staphylococcus aureus in biofilms in a dose-dependent manner. When loaded into chitosan nanoparticles, it achieves sustained release, and this effect is particularly pronounced under acidic conditions. | |||||||||||||||||||||
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- [1]. Herrera-León C, et al. The impact of phosphatidylserine exposure on cancer cell membranes on the activity of the anticancer peptide HB43. The FEBS journal. 2022 Apr;289(7):1984-2003. [Content Brief]
- [2]. Keikhosravani P, et al. Developing antibacterial HB43 peptide-loaded chitosan nanoparticles for biofilm treatment. International journal of biological macromolecules. 2025 May;310(Pt 2):143397. [Content Brief]
Keywords
