939981-39-2
939981-39-2
Chemical Structure
RG7112
Synonym(s): RO5045337
- CAS No.: 939981-39-2
- Formula:C38H48Cl2N4O4S
- Molecular Weight:727.78
IUPAC Name: ((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl)(4-(3-(methylsulfonyl)propyl)piperazin-1-yl)methanone
InChIKey: QBGKPEROWUKSBK-QPPIDDCLSA-N
SMILES: C[C@@]1([C@](C)(N(C(C2=CC=C(C=C2OCC)C(C)(C)C)=N1)C(N3CCN(CC3)CCCS(=O)(C)=O)=O)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Biological Activity: RG7112 is a potent, selective, orally active and blood-brain barrier crossed MDM2-p53 inhibitor, with an IC50 of 18 nM and a KD of 11 nM for binding to MDM2[1].
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RG7112 | 99.80% | RG7112 is a potent, selective, orally active and blood-brain barrier crossed MDM2-p53 inhibitor, with an IC50 of 18 nM and a KD of 11 nM for binding to MDM2. | ||||||||||||||||||||
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RG7112 (Standard) | ≥98% | RG7112 (Standard) is the analytical standard of RG7112 (HY-10959). This product is intended for research and analytical applications. RG7112 is a potent, selective, orally active and blood-brain barrier crossed MDM2-p53 inhibitor, with an IC50 of 18 nM and a Kd of 11 nM for binding to MDM2. | ||||||||||||||||||||
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