94059-38-8
94059-38-8
Chemical Structure
3′-Azido-2′,3′-dideoxy-GTP
Synonym(s): AZddGTP
- CAS No.: 94059-38-8
- Formula:C10H15N8O12P3
- Molecular Weight:532.19
InChIKey: JZBFFCANYXZLES-KVQBGUIXSA-N
SMILES: O=P(OP(OP(O)(O)=O)(O)=O)(O)OC[C@H]1O[C@@H](N(C=N2)C3=C2C(N=C(N)N3)=O)C[C@@H]1N=[N+]=[N-]
Biological Activity: 3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective telomerase inhibitor with a Ki value of 1.5 μM. 3′-Azido-2′,3′-dideoxy-GTP can be incorporated into the 3′-terminus of DNA by telomerase. 3′-Azido-2′,3′-dideoxy-GTP inhibits telomerase activity in HeLa cells in vitro[1].
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3′-Azido-2′,3′-dideoxy-GTP | 3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective telomerase inhibitor with a Ki value of 1.5 μM. 3′-Azido-2′,3′-dideoxy-GTP can be incorporated into the 3′-terminus of DNA by telomerase. 3′-Azido-2′,3′-dideoxy-GTP inhibits telomerase activity in HeLa cells in vitro. | |||||||||||||||||||||
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References
Keywords
