942577-31-3
Chemical Structure
NP213
- CAS No.: 942577-31-3
- Formula:C42H84N28O7
- Molecular Weight:1093.30
IUPAC Name: 1,1',1'',1''',1'''',1''''',1''''''-(((2S,5S,8S,11S,14S,17S,20S)-3,6,9,12,15,18,21-heptaoxo-1,4,7,10,13,16,19-heptaazacyclohenicosane-2,5,8,11,14,17,20-heptayl)heptakis(propane-3,1-diyl))heptaguanidine
InChIKey: NVZLKNHDHPPJHL-RMIXPHLWSA-N
SMILES: N=C(N)NCCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](N1)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C1=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O
Biological Activity: NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections[1][2].
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NP213 | NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections. | |||||||||||||||||||||
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References
- [1]. Mercer DK,et al. Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02117-18 [Content Brief]
- [2]. Neelabh, et al. Sequential and Structural Aspects of Antifungal Peptides from Animals, Bacteria and Fungi Based on Bioinformatics Tools.Probiotics Antimicrob Proteins. 2016 Jun;8(2):85-101. [Content Brief]
