946417-21-6
946417-21-6
Chemical Structure
BPH-675
- CAS No.: 946417-21-6
- Formula:C24H23NO9P2S
- Molecular Weight:563.45
IUPAC Name: (1-hydroxy-2-(3'-(naphthalene-2-sulfonamido)-[1,1'-biphenyl]-3-yl)ethane-1,1-diyl)bis(phosphonic acid)
InChIKey: MZVWVRVNMXTDAK-UHFFFAOYSA-N
SMILES: O=P(O)(C(CC1=CC=CC(C2=CC=CC(NS(=O)(C3=CC4=C(C=CC=C4)C=C3)=O)=C2)=C1)(P(O)(O)=O)O)O
Biological Activity: BPH-675 is a large bisphosphonate inhibitor with long hydrophobic side chains and a potent and selective geranylgeranyl diphosphate synthase (GGPPS) inhibitor with an IC50 of 0.71 μM. GGPPS inhibitor promotes HUVEC apoptosis[1][2].
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BPH-675 | BPH-675 is a large bisphosphonate inhibitor with long hydrophobic side chains and a potent and selective geranylgeranyl diphosphate synthase (GGPPS) inhibitor with an IC50 of 0.71 μM. GGPPS inhibitor promotes HUVEC apoptosis. | |||||||||||||||||||||
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References
- [1]. Guo RT, et al. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10022-7. [Content Brief]
- [2]. Chong D, et al. Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo. J Genet Genomics. 2021 Apr 20;48(4):300-311. [Content Brief]
