946615-43-6
946615-43-6
Chemical Structure
AMG0347
- CAS No.: 946615-43-6
- Formula:C24H26F3N3O2
- Molecular Weight:445.48
IUPAC Name: (E)-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide
InChIKey: YCDWBIUKUBHSKQ-FMIVXFBMSA-N
SMILES: O=C(NC1=C2CC(O)CCC2=CC=C1)/C=C/C3=CC=C(C(F)(F)F)N=C3N4CCCCC4
Biological Activity: AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC50 = 0.2 nm), protons (IC50= 0.8 nm), or capsaicin (IC50 = 0.7 nm)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AMG0347 | 99.02% | AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC50 = 0.2 nm), protons (IC50= 0.8 nm), or capsaicin (IC50 = 0.7 nm). | ||||||||||||||||||||
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