950388-70-2
950388-70-2
Chemical Structure
TQ416
- CAS No.: 950388-70-2
- Formula:C21H21N3OS
- Molecular Weight:363.48
InChIKey: BLJJVKJNAPFGDP-UHFFFAOYSA-N
SMILES: CC(C=C1)=CC=C1OCCSC2=NN=C3C=C(C)C4=C(N32)C(C)=CC=C4
Biological Activity: TQ416 is a non-competitive inhibitor of paraoxonase 2 (PON2) with an IC50 of 0.775 μM for PON2. TQ416 inhibits PON2 lactonase activity, blocking PON2-dependent 3OC12HSL hydrolysis and intracellular acidification, thereby modulating mitochondrial function, Ca2+, apoptosis, and cell cycle-related responses. TQ416 is useful for research on PON2 biology and bacterial quorum sensing-related host responses[1][2][3].
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TQ416 | TQ416 is a non-competitive inhibitor of paraoxonase 2 (PON2) with an IC50 of 0.775 μM for PON2. TQ416 inhibits PON2 lactonase activity, blocking PON2-dependent 3OC12HSL hydrolysis and intracellular acidification, thereby modulating mitochondrial function, Ca2+, apoptosis, and cell cycle-related responses. TQ416 is useful for research on PON2 biology and bacterial quorum sensing-related host responses. | |||||||||||||||||||||
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References
- [1]. Bianconi E, et al. Synthesis and structure-activity relationship study of a library of 1-substituted [1,2,4]triazolo[4,3-a]quinolines as valuable chemical probes for paraxonase-2 (PON2). Journal of Enzyme Inhibition and Medicinal Chemistry. 2026;41(1):2643935.
- [2]. Tao S, et al. N-(3-oxododecanoyl)-l-homoserine lactone modulates mitochondrial function and suppresses proliferation in intestinal goblet cells. Life sciences. 2018 May 15;201:81-88.
- [3]. Horke S, et al. Novel Paraoxonase 2-Dependent Mechanism Mediating the Biological Effects of the Pseudomonas aeruginosa Quorum-Sensing Molecule N-(3-Oxo-Dodecanoyl)-L-Homoserine Lactone. Infection and immunity. 2015 Sep;83(9):3369-80.
