958295-17-5
958295-17-5
Chemical Structure
AGN 196996
- CAS No.: 958295-17-5
- Formula:C24H20BrNO5
- Molecular Weight:482.32
IUPAC Name: 4-(3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzamido)benzoic acid
InChIKey: BUGXGZOGQGUTBC-UHFFFAOYSA-N
SMILES: BrC1=CC(C(NC2=CC=C(C(O)=O)C=C2)=O)=CC(C(C3=CC=C(C)C=C3)=O)=C1OCC
Biological Activity:
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AGN 196996 | 99.76% | AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). | ||||||||||||||||||||
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References
- Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. [Content Brief]
- Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8. [Content Brief]
Keywords
