959740-39-7
Chemical Structure
JNJ-39220675
- CAS No.: 959740-39-7
- Formula:C21H24FN3O2
- Molecular Weight:369.43
IUPAC Name: (4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenoxy)pyridin-3-yl)methanone
InChIKey: IQOWHZHNGJXGHG-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C2CCC2)CCC1)C3=CC=C(OC4=CC=C(F)C=C4)N=C3
Biological Activity: JNJ-39220675 is a selective and brain-penetrating histamine H3 receptor antagonist with activity in regulating alcohol stimulation and reward. JNJ-39220675 is effective in reducing alcohol intake and preference in alcohol-preferring rats. JNJ-39220675 does not affect the ataxic effects of alcohol, the rate of alcohol elimination, or alcohol-induced nucleocapsid dopamine release[1].
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JNJ-39220675 | JNJ-39220675 is a selective and brain-penetrating histamine H3 receptor antagonist with activity in regulating alcohol stimulation and reward. JNJ-39220675 is effective in reducing alcohol intake and preference in alcohol-preferring rats. JNJ-39220675 does not affect the ataxic effects of alcohol, the rate of alcohol elimination, or alcohol-induced nucleocapsid dopamine release. | |||||||||||||||||||||
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