98205-89-1
98205-89-1
Chemical Structure
Flesinoxan hydrochloride
Synonym(s): DU-29373
- CAS No.: 98205-89-1
- Formula:C22H27ClFN3O4
- Molecular Weight:451.92
InChIKey: LZBWQEXVQZCBDJ-GMUIIQOCSA-N
SMILES: OC[C@H]1OC2=CC=CC(N3CCN(CC3)CCNC(C4=CC=C(C=C4)F)=O)=C2OC1.Cl
Biological Activity: Flesinoxan hydrochloride is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan hydrochloride also has effective anxiolytic/antidepressant effects[1][2][3].
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Flesinoxan hydrochloride | Flesinoxan hydrochloride is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan hydrochloride also has effective anxiolytic/antidepressant effects. | |||||||||||||||||||||
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References
- [1]. Hadrava V, et al. Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. Neuropharmacology. 1995 Oct;34(10):1311-26. [Content Brief]
- [2]. Schoeffter P, et al. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br J Pharmacol. 1988 Nov;95(3):975-85. [Content Brief]
- [3]. Rodgers RJ, et al. Antianxiety and behavioral suppressant actions of the novel 5-HT1A receptor agonist, flesinoxan. Pharmacol Biochem Behav. 1994 Aug;48(4):959-63. [Content Brief]
