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Art. -Nr.: HY-100295

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(4-Acetamidocyclohexyl) nitrate

(Synonyms: BM121307)

(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.

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CAS. Nr.: 137213-91-3
Formel: C₈H₁₄N₂O₄
Molecular Weight:202.21

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

(4-Acetamidocyclohexyl) nitrate Chemical Structure

CAS. Nr.: 137213-91-3

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Biologische Aktivität
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- In Vivo
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Biologische Aktivität

Beschreibung

(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.

In Vivo

The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 137213-91-3
Molecular Weight 202.21
Formel C₈H₁₄N₂O₄
SMILES

CC(N[C@@H]1CC[C@@H](O[N+]([O-])=O)CC1)=O
Synonyms

BM121307
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

Animal Administration^[1]

Dogs^[1]

The biotransformation of BM121307 in the dog is examined after oral and intravenous administration. For that purpose, the organic nitrate is synthesized as radioactive [¹⁴C]- and as [¹³C]-labeled compounds. The defined isotopic mixture is administered to the dogs. Within the examined period of 168 h, the elimination of BM121307 is measured^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zell C, et al. Biotransformation of the organic nitrate trans-N-(4-nitroxycyclohexyl)acetamide in dogs. Arzneimittelforschung. 1994 Sep;44(9):1021-8. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

(4-Acetamidocyclohexyl) nitrate

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(4-Acetamidocyclohexyl) nitrate

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Lificiguat

Nelociguat

NS-2028

Vericiguat (Standard)

Cinaciguat hydrochloride

Praliciguat

Riociguat (Standard)

Biologische Aktivität

Chemical Information

Protokoll

Reinheit & Dokumentation

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Help & FAQs

(4-Acetamidocyclohexyl) nitrate

Vericiguat

Linaclotide

Riociguat

Cinaciguat

BAY 41-2272

Lificiguat

Nelociguat

NS-2028

Vericiguat (Standard)

Cinaciguat hydrochloride

Praliciguat

Riociguat (Standard)

Biologische Aktivität

Chemical Information

Protokoll

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

(4-Acetamidocyclohexyl) nitrate Related Classifications

HY-100295 Related Classifications