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Art. -Nr.: HY-161021

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AC2 selective-IN-1

AC2 selective-IN-1 (compound 14) is a? potent (IC₅₀=4.45 μM), non-toxic, and selective mAC2 inhibitor.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₄₁H₄₇N₈O₈P
Molecular Weight:810.83

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

AC2 selective-IN-1 Chemical Structure

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AC2 selective-IN-1 (compound 14) is a? potent (IC₅₀=4.45 μM), non-toxic, and selective mAC2 inhibitor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human CCRF-CEM cells by CellTiter-Glo 2.0 assay Cytotoxicity against human CCRF-CEM cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
HeLa S3	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human HeLa S3 cells by CellTiter-Glo 2.0 assay Cytotoxicity against human HeLa S3 cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
HepG2	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human HepG2 cells by CellTiter-Glo 2.0 assay Cytotoxicity against human HepG2 cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
HL-60	IC₅₀	10 μM Compound: 14	Cytotoxicity against human HL-60 cells by CellTiter-Glo 2.0 assay Cytotoxicity against human HL-60 cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
NHDF	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human NHDF cells by CellTiter-Glo 2.0 assay Cytotoxicity against human NHDF cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]

Chemical Information

Molecular Weight 810.83
Formel C₄₁H₄₇N₈O₈P
SMILES

NC1=C2C(N(CCOCP(N[C@H](C(OC(C)C)=O)CC3=CC=CC=C3)(N[C@@H](CC4=CC=CC=C4)C(OC(C)C)=O)=O)C=C2C5=CC=CC(C(N6)=NOC6=O)=C5)=NC=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pavel Kraina, et al. Discovery of a potent and selective human AC2 inhibitor based on 7-deazapurine analogues of adefovir. Bioorg Med Chem. 2023. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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