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Art. -Nr.: HY-182056

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Antibacterial agent 331

Antibacterial agent 331 is an antibacterial agent with anti-biofilm activity. Antibacterial agent 331 exhibits activity against a variety of Gram-positive and Gram-negative bacteria. Antibacterial agent 331 eliminates MRSE 62 and promotes the repair of infected wounds in mouse models. Antibacterial agent 331 can be used for research on infections.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₆H₂₉FN₆O₅S
Molecular Weight:556.61

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 331 Chemical Structure

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Preis

Verfügbarkeit

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Antibacterial agent 331 (compound A4) (24 h) potently inhibits the growth of standard Gram-positive bacterial strains (Listeria monocytogenes CMCC54004, Staphylococcus aureus ATCC29213, Enterococcus faecalis BNCC186300) and Gram-negative bacterial strains (Salmonella typhimurium SL1344, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 15442), with MIC values ranging from <0.0625 to 0.25 μg/mL^[1].
Antibacterial agent 331 (24 h) potently inhibits the growth of clinically isolated drug-resistant Gram-positive strains (MRSA 62, L970, L971; MRSE 61, 62, 63; VRE 11, 12, 13), with MIC values ranging from 0.125 to 16 μg/mL^[1].
Antibacterial agent 331 (8 μg/mL; 24 h) eliminates 58.1% of mature MRSE 62 biofilms^[1].
Antibacterial agent 331 (24 h) exhibits low cytotoxicity against L929 mouse fibroblasts, with a CC₅₀ value > 128 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

L929 mouse fibroblast cells
Concentration:

/
Incubation Time:

24 h
Result:

Did not significantly reduce L929 cell viability, with a CC₅₀ value >128 μg/mL.

In Vivo

Antibacterial agent 331 (2× MIC; local administration; once daily; for 9 consecutive days) significantly reduces the bacterial load in Kunming mice infected with MRSE 62, promotes the healing of infected skin wounds, and induces only extremely mild associated inflammatory responses^[1].
Antibacterial agent 331 (50-100 mg/kg; p.o.; once daily; for 8 consecutive days) is well tolerated in Kunming mice, with no adverse effects on body weight, organ function or histomorphology observed^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming mice (male, 5-6 weeks of age, 18-22 g for biosafety study; male, 20±2 g for skin infection study)^[1]
Dosage:

2× MIC
Administration:

local; once daily; 9 days
Result:

Reduced MRSE 62 bacterial load by approximately 3.1 log₁₀ relative to controls.
Enhanced wound healing, with a higher wound contraction rate on day 3 compared to controls and reference groups.
Induced minimal inflammatory cell infiltration and near-normal cell morphology in treated tissue, unlike control and ciprofloxacin groups with obvious inflammatory cell infiltration and tissue abnormalities.

Chemical Information

Molecular Weight 556.61
Formel C₂₆H₂₉FN₆O₅S
SMILES

NC1=CC(NC(SCCCCC(N2CCN(CC2)C3=C(C=C4C(C(C(O)=O)=CN(C4=C3)C5CC5)=O)F)=O)=N1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Du H, et al. Design, synthesis and biological evaluation of novel fluoroquinolone-uracil hybrids against methicillin-resistant Staphylococcus Epidermidis (MRSE) infections. Bioorg Chem. 2026;173:109657. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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