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Art. -Nr.: HY-P992155

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Arevirumab

Name: Arevirumab
Brand: MedChemExpress
SKU: HY-P992155
Availability: PreOrder

(Synonyms: Arevirumab-3)

Arevirumab (Arevirumab-3) is a pan-lineage neutralizing human monoclonal antibody cocktail (8.9F, 12.1F, 37.D). Arevirumab protects cynomolgus monkeys from severe Lassa fever caused by lineage II and III LASV isolates. Arevirumab is applicable to research related to Lassa fever.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Arevirumab Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vivo
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Lassa virus

In Vivo

Arevirumab-3 (15 mg/kg of each monoclonal antibody in the cocktail; i.v.; days 8, 11, and 14 post-challenge) provides 100% survival to cynomolgus macaques with advanced Lassa fever caused by LASV lineage II strain 0043/LV/14, and significantly reduces viral loads in circulation and tissues^[1].
Arevirumab-3 (15 mg/kg of each monoclonal antibody in the cocktail; i.v.; days 8, 11, and 14 post-challenge) provides 100% survival to cynomolgus macaques with advanced Lassa fever caused by LASV lineage III strain Ojoko, and significantly reduces viral loads in circulation and tissues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Macaca fascicularis (healthy adult, Asian origin, male and female, age ~4 to 5.5 y, weight 3.0 to 5.2 kg)^[1]
Dosage:

15 mg/kg of each monoclonal antibody (8.9F, 12.1F, 37.2D) in the Arevirumab-3 cocktail
Administration:

i.v.; days 8, 11, and 14 post-challenge
Result:

Ensured 100% survival of all 5 treated macaques at study end.
Cleared infectious LASV from circulation by day 11 post-challenge in all treated animals.
Eliminated circulating viral genomic RNA (vRNA) in all treated animals by day 21 post-challenge.
Reduced tissue vRNA levels significantly compared to untreated control (multiplicity-adjusted P ≤ 0.020 for all assayed tissues).
Caused a significant difference in peak viremia (measured by both vRNA and infectious virus) between treated animals and control cohorts (P = 0.004 and P = 0.007, respectively).

Animal Model:

Macaca fascicularis (healthy adult, Asian origin, male and female, age ~3 to 7 y, weight 3.0 to 5.4 kg)^[1]
Dosage:

15 mg/kg of each monoclonal antibody (8.9F, 12.1F, 37.2D) in the Arevirumab-3 cocktail
Administration:

i.v.; days 8, 11, and 14 post-challenge
Result:

Ensured 100% survival of all 5 treated macaques at study end.
Cleared infectious LASV from circulation by day 14 post-challenge in all treated animals.
Eliminated circulating vRNA in all treated animals by day 14 post-challenge.
Reduced tissue vRNA levels significantly compared to untreated control (multiplicity-adjusted P ≤ 0.031 for most assayed tissues).
Caused a significant difference in peak vRNA load between the Arevirumab-3 cohort and controls (multiplicity-adjusted P = 0.027).

Target

GPC

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Anwendung

ELISA, FACS, Functional assay

Chemical Information

SMILES

[Arevirumab]
Synonyms

Arevirumab-3
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Cross RW, et al. A human monoclonal antibody combination rescues nonhuman primates from advanced disease caused by the major lineages of Lassa virus. Proc Natl Acad Sci U S A. 2023;120(34):e2304876120. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vivo
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Arevirumab

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)