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Art. -Nr.: HY-171894

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AXSP0056BS

AXSP0056BS is an allosteric GTP cyclohydrolase I (GCH1) inhibitor with an IC₅₀ of 4 μM. AXSP0056BS is applicable to the research of neuropathic and inflammatory pain disorders.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

The AXSP0056BS was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.

Formel: C₅H₄N₄O₂S
Molecular Weight:184.18

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AXSP0056BS Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AXSP0056BS is an allosteric GTP cyclohydrolase I (GCH1) inhibitor with an IC₅₀ of 4 μM. AXSP0056BS is applicable to the research of neuropathic and inflammatory pain disorders^[1].

In Vitro

AXSP0056BS (1 mM; 2-10 days) binds to the allosteric pocket of GCH1, induces quaternary structure compaction and increased flexibility of the loop adjacent to the active site, thereby converting the enzyme into an inhibitory conformation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 184.18
Formel C₅H₄N₄O₂S
SMILES

O=C(N1)SC2=C1C(NC(N)=N2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ebenhoch R, et al. A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc Natl Acad Sci U S A. 2020;117(50):31838-31849. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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