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Art. -Nr.: HY-190158

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AZ-007

AZ-007 is a thiophene-2-carboximidamide fragment that binds to the 14-3-3σ/p53pT387 protein-protein interaction interface. AZ-007 is confirmed by X-ray crystallography to bind to the interfacial water network region between 14-3-3σ and the p53pT387 peptide, and it possesses interface selectivity. AZ-007 can be used in research related to the development of selective 14-3-3/p53 protein-protein interaction stabilizers.

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CAS. Nr.: 2488429-19-0
Formel: C₁₄H₁₂N₄S
Molecular Weight:268.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AZ-007 Chemical Structure

CAS. Nr.: 2488429-19-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

In Vitro

AZ-007 binds to the 14-3-3σ/p53^pT387 interface in X-ray crystallography (PDB 6RWH) and produces no additional electron density in 14-3-3σ/TAZ^pS89 crystals, supporting selective targeting of the p53-bound interface over the TAZ-bound interface^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 2488429-19-0
Molecular Weight 268.34
Formel C₁₄H₁₂N₄S
SMILES

N=C(N)C1=CC(C2=CC=CC=C2)=C(C3=CN=CN3)S1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Guillory X, et al. Fragment-based Differential Targeting of PPI Stabilizer Interfaces. Journal of medicinal chemistry. 2020 Jul 09;63(13):6694-6707.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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