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Art. -Nr.: HY-163286

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BODIQPy-TPA

BODIQPy-TPA is a lipophilic probes, which induces ferroptosis in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm.

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CAS. Nr.: 2738333-02-1
Formel: C₃₃H₂₃BF₂N₄O
Molecular Weight:540.37

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

BODIQPy-TPA Chemical Structure

CAS. Nr.: 2738333-02-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

BODIQPy-TPA (5 μM) ferrostatin-dependently reveals photocytotoxicity with IC₅₀ of 0.51 μM in B16 cells under blue LED irradiation, downregulates expression of ferritin heavy polypeptide 1 (FTH1) ^[1].
BODIQPy-TPA (5 μM) increases levels of triacylglycerol (TG) and downregulates phosphatidylcholine (PC) with light irradiation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

B16
Concentration:

0-50 μM
Incubation Time:

48 h
Result:

Inhibited B16 cells viability, decreased the cytotoxicity with presence of ferrostatin.

Western Blot Analysis^[1]

Cell Line:

B16
Concentration:

5 μM
Incubation Time:

48 h
Result:

Decreased levels of FTH1.

Related Protocols :

Ferroptosis Solutions

Chemical Information

CAS. Nr. 2738333-02-1
Molecular Weight 540.37
Formel C₃₃H₂₃BF₂N₄O
SMILES

[F-][B+3]1([N-]2C(C3=CC(/C=C/C4=CC=C(C=C4)N(C5=CC=CC=C5)C6=CC=CC=C6)=CC=[N]31)=NC7=CC=CC=C7C2=O)[F-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xing Z, et al., Endoplasmic Reticulum-Targeting Quinazolinone-Based Lipophilic Probe for Specific Photoinduced Ferroptosis and Its Induced Lipid Dynamic Regulation. J Med Chem. 2024 Feb 8;67(3):1900-1913. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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