497180-72-0
497180-72-0
Chemical Structure
LNP-911
- CAS. Nr.: 497180-72-0
- Formula:C11H12ClIN2
- Molecular Weight:334.58
InChIKey: KLIBTBNNCGHLPY-UHFFFAOYSA-N
SMILES: CC1CCC(NC2=CC=C(I)C=C2Cl)=N1
Biological Activity: LNP-911 is a ligand for the I1 imidazoline receptor. LNP-911 allosterically modulates I1Rs and enhances the effect of agonists on Forskolin (HY-15371)-stimulated cAMP accumulation. LNP-911 exists mainly as a stable imine tautomer. After radioiodination, LNP-911 serves as a selective high-affinity radioligand for characterization studies of I1Rs in membrane preparations. LNP-911 can be used in hypertension-related research[1][2][3].
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LNP-911 | LNP-911 is a ligand for the I1 imidazoline receptor. LNP-911 allosterically modulates I1Rs and enhances the effect of agonists on Forskolin (HY-15371)-stimulated cAMP accumulation. LNP-911 exists mainly as a stable imine tautomer. After radioiodination, LNP-911 serves as a selective high-affinity radioligand for characterization studies of I1Rs in membrane preparations. LNP-911 can be used in hypertension-related research. | |||||||||||||||||||||
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References
- [1]. Greney H, et al. [125I]2-(2-chloro-4-iodo-phenylamino)-5-methyl-pyrroline (LNP 911), a high-affinity radioligand selective for I1 imidazoline receptors. Molecular pharmacology. 2002 Jul;62(1):181-91. [Content Brief]
- [2]. Nikolic K, et al. Imidazoline antihypertensive drugs: selective i(1) -imidazoline receptors activation. Cardiovascular therapeutics. 2012 Aug;30(4):209-16.
- [3]. Remko M, et al. Theoretical study of structure, pKa, lipophilicity, solubility, absorption, and polar surface area of some centrally acting antihypertensives. Bioorganic & medicinal chemistry. 2006 Mar 15;14(6):1715-28. [Content Brief]
