64134-31-2
Chemical Structure
Hepta-histidine
- CAS. Nr.: 64134-31-2
- Formula:C42H51N21O8
- Molecular Weight:978.01
IUPAC Name: L-histidyl-L-histidyl-L-histidyl-L-histidyl-L-histidyl-L-histidyl-L-histidine
InChIKey: HPQCNRDTTAGZEJ-POFDKVPJSA-N
SMILES: [C@H](CC1=CN=CN1)(C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CN=CN3)C(N[C@@H](CC4=CN=CN4)C(O)=O)=O)=O)=O)NC([C@H](CC5=CN=CN5)NC([C@H](CC6=CN=CN6)NC([C@H](CC7=CN=CN7)N)=O)=O)=O
Biological Activity: Hepta-histidine is an inhibitor of Ku70-Huntingtin protein interaction. Hepta-histidine can reverse the morphological abnormalities of primary neurons differentiatied from hiPSCs. Hepta-histidine prolongs the lifespan in severe Huntington’s disease R6/2 mouse model. Hepta-histidine ameliorates DNA damage in vitro. Hepta-histidine can be used to study anti-aggregation agent against Tau-associated neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease[1][2].
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Hepta-histidine | Hepta-histidine is an inhibitor of Ku70-Huntingtin protein interaction. Hepta-histidine can reverse the morphological abnormalities of primary neurons differentiatied from hiPSCs. Hepta-histidine prolongs the lifespan in severe Huntington’s disease R6/2 mouse model. Hepta-histidine ameliorates DNA damage in vitro. Hepta-histidine can be used to study anti-aggregation agent against Tau-associated neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease. | |||||||||||||||||||||
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References
- [1]. Kondo K, et al., Hepta-Histidine Inhibits Tau Aggregation. ACS Chem Neurosci. 2021 Aug 18;12(16):3015-3027. [Content Brief]
- [2]. Imamura T, et al., Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016 Sep 22;6:33861. [Content Brief]
