CGP-49823
CGP-49823 is an orally active and highly selective antagonist of the neurokinin 1 receptor (NK1 receptor). CGP-49823‘s potency is significantly higher in isolated spinal cords of hamsters than in those of rats. CGP 49823 exhibits a significant anti-anxiety effect in social interaction experiments of rats, and its tolerance develops slowly, without causing anxiety-like withdrawal reactions after discontinuation. CGP-49823 can be used in anxiety and depression research.
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- CAS. Nr.: 150705-88-7
- Formel: C31H33N3O
- Molecular Weight:463.61
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| U-373MG ATCC | IC50 |
12 nM
Compound: (+)-2, (CGP-49823)
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Compound was tested for inhibition of substance P induced phosphatidyl inositol turnover in human U-373 cells
Compound was tested for inhibition of substance P induced phosphatidyl inositol turnover in human U-373 cells
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10.1016/0960-894X(96)00287-9 |
Chemical Information
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CAS. Nr. 150705-88-7
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Molecular Weight 463.61
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Formel C31H33N3O
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SMILES
O=C(N1[C@H](CC2=CC=CC=C2)C[C@@H](NCC3=CC=NC4=CC=CC=C34)CC1)C5=CC(C)=CC(C)=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. File SE. Anxiolytic action of a neurokinin1 receptor antagonist in the social interaction test. Pharmacol Biochem Behav. 1997 Nov;58(3):747-52. [Content Brief]
[2]. Pozza MF, et al. The potency of the novel tachykinin receptor antagonist CGP49823 at rat and gerbil motoneurones in vitro. Eur J Pharmacol. 1998 Jan 26;342(2-3):203-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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