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Art. -Nr.: HY-160073A

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Florensocatib hydrate

Name: Florensocatib hydrate
Brand: MedChemExpress
SKU: HY-160073A
Availability: PreOrder

(Synonyms: HSK31858 hydrate)

Florensocatib hydrate (HSK31858 hydrate) is a potent reversible dipeptidyl peptidase 1 (DPP1) inhibitor with an IC₅₀ of 1.6 nM against DPP1. Florensocatib hydrate inhibits DPP1 and thereby reduces DPP1-dependent maturation and activation of neutrophil serine proteases (NSPs). Florensocatib hydrate can be used in studies of bronchiectasis and neutrophilic inflammation.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2971064-13-6
Formel: C₂₃H₂₅FN₄O₅
Molecular Weight:456.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Florensocatib hydrate Chemical Structure

CAS. Nr.: 2971064-13-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[2]

DPP1

1.6 nM (IC₅₀)

Alle Dipeptidyl Peptidase Isoform-spezifische Produkte anzeigen :

In Vitro

Florensocatib hydrate (HSK31858 hydrate) exhibits high inhibitory potency against neutrophil serine protease activity in vitro^[1].
Florensocatib hydrate (30 min) potently inhibits the activity of recombinant human DPP1 enzyme, with an IC₅₀ value of 1.6 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 2971064-13-6
Molecular Weight 456.47
Formel C₂₃H₂₅FN₄O₅
SMILES

CN1C2=CC(C3=CC(F)=C(C=C3)C[C@@H](C#N)NC([C@@H]4CNCCCO4)=O)=CC=C2OC1=O.O
Synonyms

HSK31858 hydrate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhong N, et al. Florensocatib in adults with bronchiectasis: The HOPE-BE trial protocol and baseline demographic characteristics. ERJ Open Research. 2026; in press.

[2]. Fan J, et al. Dipeptidyl peptidase 1 inhibitor polymorph, preparation method and use therefor. WO2023160579A1. World Intellectual Property Organization. 2023-08-31.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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