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Art. -Nr.: HY-N11643

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Ganoderic acid Mk

(Synonyms: GA-Mk)

Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research.

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CAS. Nr.: 110024-14-1
Formel: C₃₄H₅₀O₇
Molecular Weight:570.76

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Ganoderic acid Mk Chemical Structure

CAS. Nr.: 110024-14-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Caspase-3

Caspase-9

Alle MMP Isoform-spezifische Produkte anzeigen :

Alle Caspase Isoform-spezifische Produkte anzeigen :

In Vitro

Ganoderic acid Mk (0-100 μM, 24 h) exhibits stronger cytotoxicity to human cancer cells than human normal cell lines^[1].
Ganoderic acid Mk (0-40 μM, 12-48 h) has a dose-dependent inhibitory effect on proliferation of HeLa cells^[1].
Ganoderic acid Mk (0-40 μM, 24 h) induces HeLa cells apoptosis^[1].
Ganoderic acid Mk (0-40 μM, 24 h) induces ROS burst, MMP decrease and caspase-3, -9 activities increase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Human normal cell lines (MCF-10A and HF) and cancer cell lines (HO-8910PM, SW1990, 95-D and HeLa)
Concentration:

0-100 μM
Incubation Time:

24 h
Result:

Exhibited stronger cytotoxicity to human cancer cells (IC₅₀ values were ranged within 29.8-44.2 µM) than human normal cell lines (IC₅₀ values to MCF-10A and HF were 84.5 µM and 78.4 µM, respectively).

Cell Viability Assay^[1]

Cell Line:

HeLa cells
Concentration:

0, 5, 10, 20, 40 μM
Incubation Time:

12, 24, 48 h
Result:

Showed cytotoxicity on HeLa cells in a dose- and time-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

HeLa cells
Concentration:

0, 10, 20, 40 μM
Incubation Time:

24 h
Result:

Increased the rate of early and late apoptotic cells in a dose-dependent manner in HeLa cells. GA-Mk could induce HeLa cells apoptosis in parallel with the accumulation of ROS, the loss of MMP and the activation of activities of caspases.

Chemical Information

CAS. Nr. 110024-14-1
Molecular Weight 570.76
Formel C₃₄H₅₀O₇
SMILES

O=C(/C(C)=C/CC(C(C1CC([C@@]2(C)C3=CCC4[C@](C)(CCC(C4(C)C)OC(C)=O)C3=CC[C@]12C)O)C)OC(C)=O)O
Synonyms

GA-Mk
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Microorganisms
glossy ganoderma
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liu R M, et al. Anti-proliferation and induced mitochondria-mediated apoptosis of ganoderic acid Mk from Ganoderma lucidum mycelia in cervical cancer HeLa cells[J]. Latin American Journal of Pharmacy, 2012, 31(1):43-50.

[2]. Ding N, et al. Separation and determination of four ganoderic acids from dried fermentation mycelia powder of Ganoderma lucidum by capillary zone electrophoresis. J Pharm Biomed Anal. 2010 Dec 15;53(5):1224-30. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Ganoderic acid Mk

Alle MMP Isoform-spezifische Produkte anzeigen

Alle Caspase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Ganoderic acid Mk Related Classifications

HY-N11643 Related Classifications