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STOX1 - storkhead box 1 Gene

Also Known as C10orf24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 219736

About STOX1

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:68,827,531-68,895,432 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in brain (RPKM 2.8), fat (RPKM 2.4) and 21 other tissues.

Summary

The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

STOX1 Products (4)

mRNA	Protein	Name
NM_001130159.3	NP_001123631.1	storkhead-box protein 1 isoform b
NM_001130160.3	NP_001123632.1	storkhead-box protein 1 isoform c
NM_001130161.4	NP_001123633.1	storkhead-box protein 1 isoform a
NM_152709.5	NP_689922.3	storkhead-box protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22253775	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to nitrosative stress	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22253775	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22253775	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22253775	GOA
involved in positive regulation of cyclin-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	22253775	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22253775	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	22995177	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	22995177	GOA
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in regulation of mitochondrial DNA metabolic process	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in regulation of mitochondrion organization	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in regulation of response to oxidative stress	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24738702	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in centrosome	IDA IDA: Inferred from direct assay	22253775	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22253775	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22253775	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STOX1 Protein Structure

Stork_head

0
200
400
600
800
989 a.a.

Protein Preferred Names	Protein Names
storkhead-box protein 1	winged-helix domain-containing protein

STOX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	STOX1	Q6ZVD7	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	STOX1	Q6ZVD7	ADARB1	Homo sapiens	P78563-4	Y2H Array	32296183
Intra	STOX1	Q6ZVD7	ADARB1	Homo sapiens	P78563-4	Y2H Prey Pooling	32296183
Intra	STOX1	Q6ZVD7	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	31515488
Intra	STOX1	Q6ZVD7	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	25416956
Intra	STOX1	Q6ZVD7	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Preeclampsia/Eclampsia 4	PEE4 Pre-Eclampsia/Eclampsia 4 Gestational Proteinuric Hypertension Preeclampsia/Eclampsia, Type 4 Preeclampsia Eclampsia 4
Eclampsia	Eclampsia In Puerperium Postpartum Eclampsia Eclampsia, Postpartum Puerperal Eclampsia
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Severe Pre-Eclampsia	Severe Preeclampsia Antepartum Severe Pre-Eclampsia Postpartum Severe Pre-Eclampsia Severe Pre-Eclampsia, With Delivery Severe Toxemia Severe Pre-Eclampsia, Antepartum Condition Or Complication Severe Pre-Eclampsia, Postpartum Condition Or Complication Severe Puerperal Pre-Eclampsia Severe Pre-Eclamptic Toxaemia Severe Pet - [Pre-Eclamptic Toxaemia]
Patau Syndrome	Trisomy 13 Complete Trisomy 13 Syndrome Trisomy 13 Syndrome D1 Trisomy Patau'S Syndrome Complete Trisomy 13 Chromosome 13, Trisomy 13 Complete D Trisomy Syndrome Bartholin-Patau Syndrome Chromosome 13 Duplication D1 Trisomy Syndrome D>1< Trisomy Syndrome Patau Chromosome 13 Trisomy Abnormal Autosomes 13

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS13954	STOX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	STOX1	VGNC	VGNC:35414
Canis familiaris	STOX1	VGNC	VGNC:49791
Macaca mulatta	STOX1	VGNC	VGNC:78197
Mus musculus	STOX1	MGD	MGI:2684909
Rattus norvegicus	STOX1	RGD	RGD:1310622
Others	STOX1	NCBI