Sufu - SUFU negative regulator of hedgehog signaling Gene

Also Known as Su(fu)

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24069

Summary

Enables beta-catenin binding activity. Acts upstream of with a negative effect on smoothened signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; and regulation of transcription, DNA-templated. Located in cilium; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and testis. Used to study nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of Hedgehog signaling). [provided by Alliance of Genome Resources, Apr 2022]

Sufu Products (2)

mRNA Protein Name
NM_001025391.2 NP_001020562.1 suppressor of fused homolog isoform 2
NM_015752.3 NP_056567.2 suppressor of fused homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables beta-catenin binding IDA
IDA: Inferred from direct assay
11477086 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11252182 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within cytoplasmic sequestering of transcription factor IGI
IGI: Inferred from genetic interaction
16316410 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
16155214 MGI
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
16155214 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
16459298 MGI
involved in negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
27234298 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16459298 MGI
acts upstream of or within negative regulation of ubiquitin-dependent protein catabolic process IGI
IGI: Inferred from genetic interaction
19684112 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
16155214 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
16459298 MGI
acts upstream of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
16459298 MGI
acts upstream of negative effect smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
29487109 MGI
acts upstream of or within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IMP
IMP: Inferred from mutant phenotype
19684112 MGI
acts upstream of or within smoothened signaling pathway involved in ventral spinal cord interneuron specification IMP
IMP: Inferred from mutant phenotype
19684112 MGI
acts upstream of or within spinal cord dorsal/ventral patterning IMP
IMP: Inferred from mutant phenotype
16459298 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cilium IDA
IDA: Inferred from direct assay
16254602 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
20360384 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16254602 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

suppressor of fused homolog

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-105634A Nomegestrol acetate Agonist 99.73% Yes

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-162273 Antibacterial agent 189 Inhibitor / Unkown
HY-RS14007 SUFU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18155 Sufu Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24629 Sufu Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sufu NCBI NCBI:51684