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Adcyap1 - adenylate cyclase activating polypeptide 1 Gene

Also Known as Pacap

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24166

Summary

Enables neuropeptide hormone activity; pituitary Adenylate Cyclase activating polypeptide activity; and pituitary adenylate cyclase-activating polypeptide receptor binding activity. Involved in several processes, including negative regulation of acute inflammatory response; positive regulation of cell communication; and regulation of GTPase activity. Located in extracellular space and terminal bouton. Used to study Parkinsonism and acute necrotizing pancreatitis. Biomarker of cystitis. Orthologous to human ADCYAP1 (Adenylate Cyclase activating polypeptide 1). [provided by Alliance of Genome Resources, Apr 2022]

Adcyap1 Products (1)

mRNA	Protein	Name
NM_016989.2	NP_058685.1	pituitary adenylate cyclase-activating polypeptide precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables neuropeptide hormone activity	IDA IDA: Inferred from direct assay	23800469	RGD
enables pituitary adenylate cyclase activating polypeptide activity	IDA IDA: Inferred from direct assay	9603988	RGD
enables pituitary adenylate cyclase-activating polypeptide receptor binding	IDA IDA: Inferred from direct assay	8238511	RGD

Biological Process GO Annotation	Evidence	Verweise	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9603988	RGD
involved in behavioral fear response	IDA IDA: Inferred from direct assay	17641738	RGD
involved in cAMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	23800469	RGD
involved in cellular response to glucocorticoid stimulus	IEP IEP: Inferred from expression pattern	17884294	RGD
involved in histamine secretion	IDA IDA: Inferred from direct assay	17660849	RGD
involved in negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	15870074	RGD
involved in negative regulation of acute inflammatory response to antigenic stimulus	IDA IDA: Inferred from direct assay	17698245	RGD
involved in negative regulation of acute inflammatory response to non-antigenic stimulus	IDA IDA: Inferred from direct assay	20229361	RGD
involved in negative regulation of glial cell proliferation	IDA IDA: Inferred from direct assay	15870074	RGD
involved in negative regulation of muscle cell apoptotic process	IDA IDA: Inferred from direct assay	16891268	RGD
involved in negative regulation of potassium ion transport	IDA IDA: Inferred from direct assay	17498241	RGD
involved in neuron projection development	IDA IDA: Inferred from direct assay	23800469	RGD
involved in neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	23800469	RGD
involved in ovarian follicle development	IDA IDA: Inferred from direct assay	20138961	RGD
involved in pituitary gland development	IEP IEP: Inferred from expression pattern	18160680	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	23800469	RGD
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	23800469	RGD
involved in positive regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	17901570	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15968088	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	18198219	RGD
involved in positive regulation of growth hormone secretion	IDA IDA: Inferred from direct assay	18198219	RGD
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	16888221	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	18541665	RGD
involved in positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	18541665	RGD
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	23800469	RGD
involved in positive regulation of somatostatin secretion	IDA IDA: Inferred from direct assay	17660849	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	16483357	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23800469	RGD
involved in regulation of oligodendrocyte progenitor proliferation	IDA IDA: Inferred from direct assay	16989910	RGD
involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	18727050	RGD
involved in regulation of protein localization	IDA IDA: Inferred from direct assay	9603988	RGD
involved in regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	18541665	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16820725	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	16888191	RGD
involved in vasodilation	IDA IDA: Inferred from direct assay	19220306	RGD

Cellular Component GO Annotation	Evidence	Verweise	Source
located in extracellular space	IDA IDA: Inferred from direct assay	17698245	RGD
is active in neuronal dense core vesicle lumen	IDA IDA: Inferred from direct assay	9792613	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	9792613	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
pituitary adenylate cyclase-activating polypeptide	adenylate cyclase activating polypeptide 1 (pituitary) pituitary adenylate cyclase activating polypeptide 1 pituitary adenylate cyclase-activating polypeptide precursor (Pacap)

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P991123	Bocunebart	Ligand	95%	Phase 2
HY-P990777	Vipalanebart		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS00336	ADCYAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00337	ADCYAP1R1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18214	Adcyap1r1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19085	Adcyap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24691	Adcyap1r1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25575	Adcyap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adcyap1	NCBI	NCBI:116