CLIC4 - chloride intracellular channel 4 Gene

Also Known as H1; huH1; p64H1; CLIC4L; MTCLIC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25932

About CLIC4

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:24,745,447-24,844,321 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 14 paralogues. Ubiquitous expression in endometrium (RPKM 129.1), kidney (RPKM 121.8) and 25 other tissues.

Summary

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic Cancer cells). [provided by RefSeq, Jul 2008]

CLIC4 Products (1)

mRNA Protein Name
NM_013943.3 NP_039234.1 chloride intracellular channel protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
10793131 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to calcium ion IMP
IMP: Inferred from mutant phenotype
17636002 GOA
involved in keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
17636002 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
12163372 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in apical part of cell IDA
IDA: Inferred from direct assay
14569596 GOA
located in cell surface IDA
IDA: Inferred from direct assay
14569596 GOA
located in cell-cell junction IDA
IDA: Inferred from direct assay
14569596 GOA
located in centrosome IDA
IDA: Inferred from direct assay
14569596 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
10793131 GOA
located in cytosol IDA
IDA: Inferred from direct assay
10026142 GOA
colocalizes with microtubule cytoskeleton IDA
IDA: Inferred from direct assay
14569596 GOA
located in microvillus IDA
IDA: Inferred from direct assay
14569596 GOA
located in midbody IDA
IDA: Inferred from direct assay
14569596 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
14569596 GOA
located in nuclear matrix IDA
IDA: Inferred from direct assay
14569596 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
14569596 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19776349 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLIC4 Protein Structure

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (35 - 97)

  • 0
  • 100
  • 200
  • 253 a.a.
Protein Preferred Names Protein Names

chloride intracellular channel protein 4

  • chloride intracellular channel 4 like

CLIC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CLIC4 Q9Y696 TPRN Homo sapiens Q4KMQ1-2
Anti Tag CoIP
28514442
Intra
CLIC4 Q9Y696 TPRN Homo sapiens Q4KMQ1-2
Y2H Array
32296183
Intra
CLIC4 Q9Y696 TPRN Homo sapiens Q4KMQ1-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLIC4 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70120 CLIC4/Chloride intracellular channel 4 Protein, Human (His) Q9Y696 (M1-K253) ≥ 95%, as determined by reducing SDS-PAGE.

CLIC4 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82772 CLIC4 Antibody (YA2517) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P82772A CLIC4 Antibody (YA2517)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02806 CLIC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20381 Clic4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26891 Clic4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CLIC4 RGD RGD:61857
Macaca mulatta CLIC4 VGNC VGNC:71172
Mus musculus CLIC4 MGD MGI:1352754
Bos taurus CLIC4 VGNC VGNC:27442
Canis familiaris CLIC4 VGNC VGNC:39340
Others CLIC4 NCBI