CLIC4 Antibody (YA2517)(PBS only)
(Synonyms: CLIC4; Chloride intracellular channel protein 4; Intracellular chloride ion channel protein p64H1)CLIC4 Antibody (YA2517) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIC4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-F, IHC-P, ICC/IF, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:50-1:100 | 1:50-1:200 | 1:20 |
Product Details
CLIC4 Antibody (YA2517) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIC4.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 29 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 29 kDa
A synthetic peptide of human CLIC4
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CLIC4 is an In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3[1][2][3].
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Subcellular Localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasmic vesicle membrane; Single-pass membrane protein; Nucleus; Cell membrane; Single-pass membrane protein; Mitochondrion; Cell junction; Endoplasmic reticulum membrane; Single-pass membrane protein
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Expression
Tissue_specificity:Detected in epithelial cells from colon, esophagus and kidney (at protein level) . Expression is prominent in heart, kidney, placenta and skeletal muscle
Induction:Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts -
Subunit
Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Monomer. Interacts with HRH3. Interacts with AKAP9
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SwissProt ID
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Synonyms
CLIC4; Chloride intracellular channel protein 4; Intracellular chloride ion channel protein p64H1
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Research Field
Cell Biology
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