SKA2 - spindle and kinetochore associated complex subunit 2 Gene

Also Known as FAM33A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 348235

About SKA2

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:59,109,857-59,155,186 (from NCBI)

This gene has 10 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in brain (RPKM 9.5), thyroid (RPKM 8.8) and 25 other tissues.

Summary

Enables microtubule binding activity. Involved in several processes, including chromosome segregation; mitotic cell cycle; and regulation of microtubule polymerization or depolymerization. Located in spindle microtubule. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]

SKA2 Products (3)

mRNA Protein Name
NM_001100595.2 NP_001094065.1 spindle and kinetochore-associated protein 2 isoform 2
NM_001330399.2 NP_001317328.1 spindle and kinetochore-associated protein 2 isoform 3
NM_182620.4 NP_872426.1 spindle and kinetochore-associated protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables microtubule binding IDA
IDA: Inferred from direct assay
19289083 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17093495 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in attachment of mitotic spindle microtubules to kinetochore IDA
IDA: Inferred from direct assay
29487209 GOA
involved in mitotic metaphase chromosome alignment IPI
IPI: Inferred from physical interaction
28495837 GOA
involved in mitotic sister chromatid segregation IMP
IMP: Inferred from mutant phenotype
17093495 GOA
involved in regulation of microtubule polymerization or depolymerization IDA
IDA: Inferred from direct assay
19289083 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of SKA complex IDA
IDA: Inferred from direct assay
31804178 GOA
located in kinetochore IPI
IPI: Inferred from physical interaction
21633384 GOA
part of outer kinetochore IDA
IDA: Inferred from direct assay
17093495 GOA
located in spindle microtubule IDA
IDA: Inferred from direct assay
17093495 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spindle and kinetochore-associated protein 2

  • family with sequence similarity 33, member A

SKA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SKA2 Q8WVK7 IFT57 Homo sapiens Q9NWB7
Validated Y2H
32296183
Intra
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
33961781
Intra
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Anti Bait CoIP
17093495
Intra
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Pull Down
19360002
Intra
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
17093495
Intra
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Y2H
17093495
Intra
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Anti Bait CoIP
19360002
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mulibrey Nanism

  • MUL

  • Muscle-Liver-Brain-Eye Nanism

  • Pericardial Constriction And Growth Failure

  • Perheentupa Syndrome

  • Mulibrey Growth Disorder

  • Mulibrey Nanism Syndrome

  • Pericardial Constriction With Growth Failure

  • Nanism Mulibrey
Acute Poststreptococcal Glomerulonephritis

  • Post-Streptococcal Glomerulonephritis

  • Acute Post-Streptococcal Glomerulonephritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12965 SKA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SKA2 VGNC VGNC:34644
Canis familiaris SKA2 VGNC VGNC:46194
Macaca mulatta SKA2 VGNC VGNC:104651
Mus musculus SKA2 MGD MGI:1913390
Rattus norvegicus SKA2 RGD RGD:1307084
Others SKA2 NCBI