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PYGB - glycogen phosphorylase B Gene

Also Known as GPBB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5834

About PYGB

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,248,085-25,298,012 (from NCBI)

This gene has 3 transcripts (splice variants), 176 orthologues and 2 paralogues. Broad expression in colon (RPKM 67.8), heart (RPKM 66.8) and 23 other tissues.

Summary

The protein encoded by this gene is a glycogen Phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen Phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]

PYGB Products (1)

mRNA	Protein	Name
NM_002862.4	NP_002853.2	glycogen phosphorylase, brain form

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10638593	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PYGB Protein Structure

Phosphorylase

0
200
400
600
800
843 a.a.

Protein Preferred Names	Protein Names
glycogen phosphorylase, brain form	phosphorylase, glycogen

PYGB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PYGB	P11216	PYGL	Homo sapiens	P06737	Y2H Array	25416956
Intra	PYGB	P11216	PYGL	Homo sapiens	P06737	Anti Tag CoIP	33961781
Intra	PYGB	P11216	PYGL	Homo sapiens	P06737	Y2H Prey Pooling	25416956
Intra	PYGB	P11216	PYGL	Homo sapiens	P06737	Validated Y2H	25416956
Intra	PYGB	P11216	FKBP5	Homo sapiens	Q13451	Crosslink	30021884
Intra	PYGB	P11216	PYGM	Homo sapiens	P11217	Anti Tag CoIP	33961781
Intra	PYGB	P11216	PYGM	Homo sapiens	P11217	Validated Y2H	32296183
Intra	PYGB	P11216	PYGM	Homo sapiens	P11217	Y2H Array	32296183
Intra	PYGB	P11216	PYGM	Homo sapiens	P11217	Y2H Prey Pooling	32296183
Intra	PYGB	P11216	PPP1R3B	Homo sapiens	Q86XI6	Validated Y2H	32296183
Intra	PYGB	P11216	PPP1R3B	Homo sapiens	Q86XI6	Anti Tag CoIP	33961781
Intra	PYGB	P11216	PPP1R3B	Homo sapiens	Q86XI6	Y2H Array	32296183
Intra	PYGB	P11216	PPP1R3B	Homo sapiens	Q86XI6	Y2H Prey Pooling	32296183
Intra	PYGB	P11216	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	PYGB	P11216	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	PYGB	P11216	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

PYGB Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P89608	PYGB/M Antibody (YA8952)	WB, IP	human

Related Diseases

Diseases	Alias
Glycogen Storage Disease Vi	Glycogen Storage Disease Type Vi Hers Disease GSD6 Gsd Vi Hepatic Glycogen Phosphorylase Deficiency Phosphorylase Deficiency Glycogen-Storage Disease Of Liver Hers' Disease Glycogen Storage Disease Type 6 Glycogen Storage Disease 6 Gsd Type Vi Glycogenosis Type Vi Glycogen Storage Disease, Type Vi Hepatophosphorylase Deficiency Glycogenosis Liver Phosphorylase Deficiency Syndrome Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency Gsd Due To Liver Glycogen Phosphorylase Deficiency Gsd Type 6 Glycogenosis Due To Liver Glycogen Phosphorylase Deficiency Glycogenosis Type 6 Hepatic Phosphorylase Deficiency Liver Glycogen Phosphorylase Deficiency Her Glycogen Storage Disease Vib Gsd-Vi Liver Phosphorylase Deficiency Storage Disease, Glycogen, Type Vi
Glycogen Storage Disease Viii	Glycogen Storage Disease Type Viii Glycogenosis Type Viii Glycogen Storage Disease 8 Hepatic Glycogen Phosphorylase Kinase Deficiency Glycogenosis Type 8 Hepatic Phosphorylase Kinase Deficiency Pykl Phosphorylase Kinase Deficiency Of Liver Glycogen Storage Disease, Type Ix
Glycogen Storage Disease V	Mcardle Disease Myophosphorylase Deficiency Glycogen Storage Disease Type V Muscle Glycogen Phosphorylase Deficiency Pygm Deficiency Gsd V Glycogen Storage Disease, Type V Glycogenosis Type V Glycogen Storage Disease Type 5 GSD5 Pygmy Mcardle'S Disease Mcardle Type Glycogen Storage Disease Gsd Type V Pygmy, African Gsdv Gsd 5 Glycogenosis 5 Mcardle Syndrome Muscle Phosphorylase Deficiency Glycogen Storage Disease Due To Muscle Glycogen Phosphorylase Deficiency Gsd Due To Muscle Glycogen Phosphorylase Deficiency Gsd Type 5 Glycogenosis Due To Muscle Glycogen Phosphorylase Deficiency Glycogenosis Type 5 Glycogen Storage Disease 5 Gsd-V Mcardles Disease Storage Disease, Glycogen, Type V
Glycogen Storage Disease Ixa	Glycogen Storage Disease Type 9a Glycogen Storage Disease Type Ixa Glycogenosis Type 9a Glycogenosis Type Ixa Gsd Type 9a Gsd Type Ixa Gsd9a
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Myoclonic Epilepsy Of Lafora	Lafora Disease Epilepsy, Progressive Myoclonic 2b EPM2 Melf Epilepsy, Progressive Myoclonic 2a Epm2a Lafora'S Disease Lafora Body Disease Lbd Epilepsy, Progressive Myoclonic, 2a Lafora Progressive Myoclonic Epilepsy Epilepsy Progressive Myoclonic 2 Lafora Body Disorder Pme Type 2 Progressive Myoclonic Epilepsy Type 2 Progressive Myoclonus Epilepsy Type 2 Epilepsy, Progressive Myoclonic 2 Epm2b Ld Progressive Myoclonic Epilepsy 2 Progressive Myoclonic Epilepsy 2a Progressive Myoclonic Epilepsy 2b Progressive Myoclonic Epilepsy Lafora Type Epilepsy, Myoclonic, Of Lafora

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS11488	PYGB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22293	Pygb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28816	Pygb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PYGB	MGD	MGI:97828
Rattus norvegicus	PYGB	RGD	RGD:3460
Felis catus	PYGB	VGNC	VGNC:69192
Bos taurus	PYGB	VGNC	VGNC:57019
Canis familiaris	PYGB	VGNC	VGNC:52899
Macaca mulatta	PYGB	VGNC	VGNC:76631
Others	PYGB	NCBI