Dapk1 - death associated protein kinase 1 Gene

Also Known as D13Ucla1; DAP-Kinase

Species: Mus musculus

Gene Type: protein coding

Gene ID: 69635

Summary

Enables ATP binding activity; Calmodulin binding activity; and protein kinase activity. Involved in several processes, including cellular response to interferon-gamma; protein phosphorylation; and regulation of NMDA Receptor activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in urinary bladder Cancer. Orthologous to human DAPK1 (death associated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Dapk1 Products (3)

mRNA	Protein	Name
NM_001285917.1	NP_001272846.1	death-associated protein kinase 1 isoform 2
NM_029653.3	NP_083929.2	death-associated protein kinase 1 isoform 1
NM_134062.2	NP_598823.1	death-associated protein kinase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11485996	MGI
enables calmodulin binding	IDA IDA: Inferred from direct assay	11485996	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20053891	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	20053891	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to type II interferon	IMP IMP: Inferred from mutant phenotype	23071094	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IGI IGI: Inferred from genetic interaction	20053891	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	15010850	MGI
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	11485996	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11485996	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11485996	MGI
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	20141836	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15010850	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20141836	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	20141836	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
death-associated protein kinase 1	DAP kinase 1

Dapk1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	Dapk1	Q80YE7	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	20141836
Intra	Dapk1	Q80YE7	Grin2b	Mus musculus	Q01097	IF	20141836
Intra	Dapk1	Q80YE7	Grin2b	Mus musculus	Q01097	Pull Down	20141836

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-123581	Quinocetone	Activator	98.25%	Unkown
HY-179055	PROTAC DAPK1 Degrader-1	Degrader	96.70%	Unkown
HY-175477	UNC9750	Inhibitor	/	Unkown
HY-125404	DAPK-IN-1	Inhibitor	/	Unkown
HY-178967	DRAK1/2-IN-2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dapk1	NCBI	NCBI:1612